The citrus flavonoid nobiletin prevents the development of doxorubicin-induced heart failure by inhibiting apoptosis
These results indicate that NOB treatment suppressed DOX-induced cardiotoxicity by reducing apoptosis. Further study of the mechanism of this effect may lead to the development of a novel therapy for DOX-induced heart failure.
Authors
- K. Iwashita
- Philip Hawke (ORCID: https://orcid.org/0000-0002-2259-3148)
- Kana Shimizu
- Yasufumi Katanasaka (ORCID: https://orcid.org/0000-0002-1755-2157)
- Tatsuya Morimoto (ORCID: https://orcid.org/0000-0002-7054-4447)
- Maki Komiyama (ORCID: https://orcid.org/0000-0002-8827-3315)
- Akira Murakami (ORCID: https://orcid.org/0000-0002-5694-2828)
- Kiyoshi Mori (ORCID: https://orcid.org/0000-0002-7285-8351)
- Yoshiki Arakawa (ORCID: https://orcid.org/0000-0003-4626-4645)
- Toshiyuki Kan (ORCID: https://orcid.org/0000-0002-9709-6365)
- Junko Kurokawa (ORCID: https://orcid.org/0000-0002-9098-0908)
- Toshihide Hamabe‐Horiike (ORCID: https://orcid.org/0000-0001-9075-9982)
- Rinya Sato
- Makoto Inai (ORCID: https://orcid.org/0000-0001-7074-0520)
- Yoichi Sunagawa (ORCID: https://orcid.org/0000-0002-4516-2308)
- Saho Mochizuki
- Sonoka Iwashimizu
- Satoshi Shimizu (ORCID: https://orcid.org/0000-0002-7270-0781)
- Masaya Ono (ORCID: https://orcid.org/0009-0005-9717-5564)
- K. Sakamoto (ORCID: https://orcid.org/0000-0002-1665-2236)
- Masafumi Funamoto
- Koji Hasegawa
- Tomohiro Asakawa
Institutions
- University of Shizuoka (JP)
- University of Hyogo (JP)
- Kyoto University (JP)
- Kyoto Medical Center (JP)
- Shizuoka General Hospital (JP)
Publication Details
- Journal
- Journal of Pharmacological Sciences
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1016/j.jphs.2025.03.011
- Citations
- 2
- Primary Topic
- Bioactive Compounds in Plants
- Type
- article
- Field-Weighted Citation Impact
- 3.50