Plasma proteomics in patients with von Willebrand disease and hemophilia A highlights von Willebrand factor as main determinant of response to desmopressin treatment
This study showed the selective increase of VWF and VWFpp 1 to 2 hours after DDAVP infusion and highlighted the interindividual variance in VWF clearance. Additionally, a delayed acute-phase response in a subgroup of patients suggested the potential role of inflammatory mechanisms contributing to heterogeneity of response.
Authors
- Tirsa T van Duijl
- Maartje van den Biggelaar (ORCID: https://orcid.org/0000-0001-6970-5496)
- Alexander B. Meijer (ORCID: https://orcid.org/0000-0002-5447-7838)
- Karin Fijnvandraat (ORCID: https://orcid.org/0000-0003-0904-4360)
- Marieke J.H.A. Kruip
- Jessica Del Castillo (ORCID: https://orcid.org/0000-0002-2305-0743)
- Eva R. Smit (ORCID: https://orcid.org/0009-0008-2001-1205)
Institutions
- Erasmus MC (NL)
- Sanquin (NL)
- Emma Kinderziekenhuis (NL)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.102738
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amsterdam University Medical Centers
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek