High resolution in-vivo reflection imaging using a self-calibrated optical setup

We introduce a novel paradigm for full-field reflective geometry measurements. Contrary to full-field optical coherence tomography, which requires careful matching of the reference beam to the sample beam, our approach employs high temporal coherence and low spatial coherence illumination. This allows the reference plane to be shifted to the camera, eliminating the need for precise alignment. We further add 3D vibration stabilization, automatic calibration of the illumination incoherence and aberration correction to achieve in-vivo high-resolution imaging of the mouse brain.