Examining sickle cell disease using high-throughput holographic cytometry

Ferroptosis, an iron-dependent form of cell death, particularly affects red blood cells due to their high hemoglobin content. We present a high-throughput holographic cytometry (HC) system to evaluate ferroptosis in sickle cell disease (SCD) samples. HC's ability to analyze millions of cells allows for detailed single-cell phenotypical profiling to identify treatment effects, making it a valuable tool for studying ferroptosis interactions in SCD cytological samples.