Quantitative phase fluctuation spectroscopy of intracellular motions in living tissue

Doppler light scattering from intracellular motions generates phase drifts that can be measured quantitatively using interferometry and digital holography. This talk reviews the current state of digital holographic optical coherence tomography used for quantitative phase analysis of intracellular dynamics. Applications include drug development, in vitro fertilization, developmental biology and cancer therapy selection. In addition, the phase sensitivity of holography enables the quantitative measurement of phase excursions related to anomalous transport inside cells, introducing “Levy-alpha spectroscopy” that may help to diagnose infections and other diseases.