An implantable, wireless, multicolor fluorescence image sensor for real-time monitoring of immunotherapy response in cancer

Visualizing real-time tumor response to immune checkpoint agents, within the complex in situ host environment - in effect a wireless biopsy - provides a heretofore unseen window into cancer biology, guiding optimal, personalized patient care. Here we present a fully wireless, implantable imager capable of multi-color florescence imaging and demonstrate proof of concept imaging of tissue samples from mouse models of cancer before and after immunotherapy to identify mechanisms of response and resistance.