Label-free hyperspectral 3D fieldoscopy with attosecond precision

We demonstrate a label-free hyperspectral microscope with attosecond precision based on femtosecond fieldoscopy. Due to the placement of the sample on the surface of the detection crystal, the response of the excitation pulse is detected in near field with exceptional resolution. The principle of field resolved spectroscopy in combination with tight focussing and precise raster scanning allows image acquisition in two spatial and one temporal dimension, enabling label-free broadband hyperspectral imaging with both spectroscopic information and phase information. The imaging capabilities of our system are demonstrated on structured indium-tin-oxide nano-crystals, paving the path for super-resolution, label-free hyperspectral imaging of biological samples.

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Published
2025-03-19
DOI
https://doi.org/10.1117/12.3042088
Primary Topic
Digital Holography and Microscopy
Type
article
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article

Label-free hyperspectral 3D fieldoscopy with attosecond precision

Nicolò Petrini, Andrea Rubino, Andreas Herbst, Hanieh Fattahi et al.
Digital Holography and Microscopy
article

Label-free hyperspectral 3D fieldoscopy with attosecond precision

Nicolò Petrini, Andrea Rubino, Andreas Herbst, Hanieh Fattahi, Anchit Srivastava, Ilka Kriegel, Soyeon Jun, Kilian Scheffter
article en

Abstract

We demonstrate a label-free hyperspectral microscope with attosecond precision based on femtosecond fieldoscopy. Due to the placement of the sample on the surface of the detection crystal, the response of the excitation pulse is detected in near field with exceptional resolution. The principle of field resolved spectroscopy in combination with tight focussing and precise raster scanning allows image acquisition in two spatial and one temporal dimension, enabling label-free broadband hyperspectral imaging with both spectroscopic information and phase information. The imaging capabilities of our system are demonstrated on structured indium-tin-oxide nano-crystals, paving the path for super-resolution, label-free hyperspectral imaging of biological samples.

Italian Institute of Technology (IT), Max Planck Institute for the Science of Light (DE)
Openalex Percentile: Top 96%
Digital Holography and Microscopy
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Label-free hyperspectral 3D fieldoscopy with attosecond precision — Nicolò Petrini, Andrea Rubino, et al. · (2025) | TGRS Research Map | TGRS