Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects

miR-199a carried by adeno-associated virus serotype 6 (AAV6) proved cardioreparative in a pig model when administered early after myocardial infarction (MI). To test whether the therapeutic efficacy of miR-199a is maintained when its administration is delayed, AAV6-miR-199a or a control AAV6 were injected 1 or 2 weeks after MI. Scar mass and cardiac contractile performance parameters were not significantly different between AAV6-miR-199a-treated and AAV6-control pigs. Nonetheless, most AAV6-miR-199a-treated pigs died from sudden death at 40 to 52 days after vector administration. For clinical translation, it appears mandatory to administer miR-199a early after MI and through modalities other than permanent expression from a viral vector.

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Publication Details

Journal
JACC Basic to Translational Science
Published
2025-03-19
DOI
https://doi.org/10.1016/j.jacbts.2024.12.014
Citations
8
Primary Topic
Congenital heart defects research
Type
article
Field-Weighted Citation Impact
6.45
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Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects

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Delayed miR-199a Administration After Myocardial Infarction Precludes Pro-Regenerative Effects

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article en
8 citations

Abstract

miR-199a carried by adeno-associated virus serotype 6 (AAV6) proved cardioreparative in a pig model when administered early after myocardial infarction (MI). To test whether the therapeutic efficacy of miR-199a is maintained when its administration is delayed, AAV6-miR-199a or a control AAV6 were injected 1 or 2 weeks after MI. Scar mass and cardiac contractile performance parameters were not significantly different between AAV6-miR-199a-treated and AAV6-control pigs. Nonetheless, most AAV6-miR-199a-treated pigs died from sudden death at 40 to 52 days after vector administration. For clinical translation, it appears mandatory to administer miR-199a early after MI and through modalities other than permanent expression from a viral vector.

JACC Basic to Translational ScienceVol. 10(5)
University of Pisa (IT), Scuola Superiore Sant'Anna (IT), King's College London (GB), Santa Maria Nuova Hospital (IT), British Heart Foundation (GB), Ospedale Santa Maria (IT), University of Pennsylvania (US), International Centre for Genetic Engineering and Biotechnology (IT)
Zero hunger
Openalex Percentile: Top 3%
Congenital heart defects research
6.45
DOIOpen Access PDFOpenAlex
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