F-box only protein 25-mediated α-actinin 1 upregulation drives ovarian cancer progression via ERK1/2 signaling in tumor cells and macrophage M2 polarization
Upregulation of ACTN1 by FBXO25 promotes the progression of ovarian cancer by activating the ERK1/2 signaling pathway and M2 polarization of macrophages. The FBXO25/ACTN1/ERK1/2 axis and M2 macrophages may represent promising targets for developing ovarian cancer treatments.
Authors
- Xujing Wang (ORCID: https://orcid.org/0000-0001-9668-8812)
- Jiamin Zhang (ORCID: https://orcid.org/0000-0003-1266-7665)
- Ziyi Yang (ORCID: https://orcid.org/0000-0001-5883-9552)
- Zhengwei Sun (ORCID: https://orcid.org/0000-0003-3289-6692)
- Zihan Zhang (ORCID: https://orcid.org/0000-0003-0957-9701)
- Xiaosheng Li (ORCID: https://orcid.org/0000-0001-8526-7094)
- Xueqiong Zhu (ORCID: https://orcid.org/0000-0002-6270-9221)
- Shuya Pan (ORCID: https://orcid.org/0000-0002-9332-1051)
Institutions
- Wenzhou Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-03-19
- DOI
- https://doi.org/10.1016/j.intimp.2025.114479
- Citations
- 3
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 2.42