Pyrimethamine treatment in breast cancer lysate-loaded dendritic cells promotes autologous T cells’ anti-tumor responses in vitro
Overall, our research points to Pyri-mediated STAT3 suppression in DCs loaded with BCL as a potentially effective therapeutic method for inducing effective T cell responses; nevertheless, additional investigation is required to evaluate the effectiveness of this approach especially in pre-clinical settings.
Authors
- Sepideh Sohrabi (ORCID: https://orcid.org/0009-0004-2736-3896)
- Behzad Baradaran (ORCID: https://orcid.org/0000-0002-8642-6795)
- Javad Masoumi (ORCID: https://orcid.org/0000-0002-8954-8384)
- Mohammad Amin Doustvandi (ORCID: https://orcid.org/0000-0002-3655-2515)
- Leili Aghebati‐Maleki (ORCID: https://orcid.org/0000-0002-0044-5961)
- Tohid Kazemi
- Elham Baghbani (ORCID: https://orcid.org/0000-0002-7529-108X)
- Zahra Ghahramanipour (ORCID: https://orcid.org/0009-0004-4118-7550)
- Shiva Alipour (ORCID: https://orcid.org/0000-0002-4596-2508)
- Bahar Naseri (ORCID: https://orcid.org/0009-0008-9557-9188)
Institutions
- Tabriz University of Medical Sciences (IR)
Publication Details
- Journal
- Human Immunology
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1016/j.humimm.2025.111290
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Tabriz University of Medical Sciences