Proposal for suitable classification of photomedical concepts

This paper proposes Reversibility-based Photomedical Classification System (RbPCS), aiming to integrate and standardize photomedical terminology. We classify the concepts based on two factors: (1) reversibility of photoexcited chromophores, (2) reversibility of chromophore-mediated cellular effect. Additionally, RbPCS has three optional affixes to indicate the perspective of action: (1) Endo- (Endogenous) and Exo- (Exogenous), (2) Rm-, Rd-, Ru-, (Recognition mediated/dependent/unrelated), (3) -T (Therapy). RbPCS is formulized by photons, chromophores, energy exchange, tissue, chromophore effect, and cellular effects. This framework provides the equations for optimizing light parameters in specific therapeutic contexts.