Imaging the entire human vitreous body in vivo with synchronous OCT window scanning and adaptive focusing

Structural features of the human vitreous body were assessed in vivo using high-resolution optical imaging with novel synchronous adaptive focus and OCT imaging window z-scans. Stitching together B-scans from different depths of the eye generated OCT tomograms of the whole eye. High resolution provided insight into the microstructure of the vitreous body with details that cannot be resolved by ultrasound imaging. In 84 eyes of 42 subjects aged 23 to 72 years, results showed age-related structural changes whose central vitreous signal intensity correlated with age (R=0.612, p<0.001). This novel OCT approach enables comprehensive analysis of vitreous degeneration, enabling enhanced diagnostics in vitreo-retinal diseases.