Tau-PET pathology in the subregions of the amygdala and its associations with cognitive performance and neuropsychiatric symptoms in autosomal dominant Alzheimer’s disease
These findings suggest that in autosomal dominant AD, tau accumulation in the amygdala begins early in the basal nucleus, while both the basal and the lateral nuclei are associated with early cognitive deficits and depressive symptoms. The nuclei's differential vulnerability to pathology underscores the importance of investigating tau spread within amygdala-associated networks, relative to the early clinical manifestations of AD. This study reinforces the potential of amygdala tau burden as a valuable biomarker for preclinical AD.
Authors
- Heidi I.L. Jacobs (ORCID: https://orcid.org/0000-0001-7620-3822)
- Reisa Anne Sperling (ORCID: https://orcid.org/0000-0003-1535-6133)
- Zoe B. Rubinstein
- Justin S. Sanchez (ORCID: https://orcid.org/0000-0003-4421-3078)
- Daniel Vásquez (ORCID: https://orcid.org/0000-0002-2586-162X)
- Ana Baena (ORCID: https://orcid.org/0000-0002-5622-4519)
- Liliana Ramírez Gómez (ORCID: https://orcid.org/0000-0001-8869-3240)
- Keith Johnson (ORCID: https://orcid.org/0000-0002-8578-5921)
- David Fernando Aguillon (ORCID: https://orcid.org/0000-0003-2283-536X)
- Jennifer R. Gatchel (ORCID: https://orcid.org/0000-0002-3892-9742)
- Jorge Alcina
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Stephanie Langella (ORCID: https://orcid.org/0000-0001-6082-5491)
- Catarina Tristão‐Pereira (ORCID: https://orcid.org/0000-0001-9660-8341)
- Clara Vila‐Castelar (ORCID: https://orcid.org/0000-0002-8779-1487)
- Vincent Malotaux (ORCID: https://orcid.org/0000-0003-0737-9220)
- Cláudia Ramos (ORCID: https://orcid.org/0000-0002-0030-4501)
- Averi Giudicessi
- Bing He (ORCID: https://orcid.org/0000-0003-3877-4872)
- Jairo E. Martínez (ORCID: https://orcid.org/0000-0002-5888-481X)
Institutions
- Boston University (US)
- Harvard University (US)
- McLean Hospital (US)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s13195-025-01711-z
- Citations
- 7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- National Institute on Aging