Exploring therapeutic paradigm focusing on genes, proteins, and pathways to combat leprosy and tuberculosis: A network medicine and drug repurposing approach
This study identifies HSP90AA1 as a potential drug target in leprosy and tuberculosis. Findings support host-directed therapy approaches and highlight the importance of computational modeling in accelerating drug discovery. The study provides a foundation for future experimental validation, including in vitro and in vivo testing to advance drug repurposing strategies for these chronic infections.
Authors
- Ahmed Subeh Alshrari (ORCID: https://orcid.org/0000-0002-3666-3848)
- Mohammed Abd Al Jawad (ORCID: https://orcid.org/0000-0002-6648-5544)
- Syed Mohammed Basheeruddin Asdaq (ORCID: https://orcid.org/0000-0003-1533-9667)
- Abida Khan (ORCID: https://orcid.org/0000-0001-5261-4010)
- Fadiyah Jadid Alanazi (ORCID: https://orcid.org/0000-0001-5457-8404)
- Mohd Imran (ORCID: https://orcid.org/0000-0002-6064-1040)
- Md. Golam Hafiz
Institutions
- Northern Border University (SA)
- Almaarefa University
Publication Details
- Journal
- Journal of Infection and Public Health
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1016/j.jiph.2025.102763
- Citations
- 8
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 11.17
Funders
- King Salman Center for Disability Research