Enhancement of functional insulin-producing cell differentiation from embryonic stem cells through MST1-silencing
The findings indicate that targeting MST1 offers a novel approach for deriving functionally mature IPCs from ESCs, potentially advancing cell replacement therapies for diabetes. This research underscores the importance of developing IPCs with competent insulin secretion for diabetes treatment in vitro.
Authors
- Bin Kong (ORCID: https://orcid.org/0000-0001-7842-0169)
- Haiyan Yang (ORCID: https://orcid.org/0000-0002-1797-304X)
- Xu Yu (ORCID: https://orcid.org/0000-0002-1881-3013)
- Xiong Li (ORCID: https://orcid.org/0000-0002-5665-1158)
- Jiarui Li (ORCID: https://orcid.org/0000-0002-9340-3962)
- Hui Li (ORCID: https://orcid.org/0000-0001-7231-8219)
- Hui Song (ORCID: https://orcid.org/0000-0003-1961-016X)
Institutions
- Ningxia Medical University (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1186/s13098-025-01666-z
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningxia Province