Photodynamic Therapy for Bladder Tumors: A Bibliometric Analysis Based on the Web of Science Database

ABSTRACT This study was performed to summarize the current research status of photodynamic therapy (PDT) for bladder tumors in China and provide a comprehensive analysis of global research frontiers and emerging trends in PDT for bladder tumors. Bladder cancer is a significant health concern, posing a significant threat to human well‐being because of its malignant nature. PDT is an effective treatment for bladder tumors. We conducted a bibliometric analysis of research literature on PDT for bladder tumors. A comprehensive search of published papers up to December 31, 2023 was performed using the Web of Science database, following the preferred reporting items for systematic reviews and meta‐analyses (PRISMA) guidelines. We analyzed the literature distribution characteristics, research frontiers, and hotspots in PDT using Citespace software, employing co‐citation and co‐word analysis protocols. We also summarized specific treatments and preliminary results from the Department of Urological Oncology at Shanghai General Hospital. In total, 465 scientific papers were retrieved, with research predominantly conducted in developed countries such as the United States, Germany, and Belgium. China leads among developing countries but still lags behind these developed countries. Key research frontiers include the design and development of photosensitizers, evaluation of PDT efficacy, optimization and standardization of clinical therapeutic procedures, and clinical transformation of photosensitizers. Although the number of research papers on PDT for bladder tumors from China is increasing, a noticeable gap remains compared with Western countries. Moving forward, the design of novel photosensitizers, the standardization and normalization of clinical therapeutic procedures, and robust efficacy assessment processes are expected to be the main areas of focus and development in PDT research globally.