Clinical profile and outcome of children with haemophilia A: The Royal Hospital, Oman’s experience

Abstract Background Data on clinical characteristics and bleeding outcome of Omani children with haemophilia A (HA) is limited. This study aims to describe the clinical profile and outcome of Omani children with HA at the Royal Hospital from 2006 to 2019. Methods This is a retrospective study including all Omani children (< 13 years) with HA at the Royal Hospital. Data included age at presentation, factor VIII (FVIII) level, treatment, complications, and bleeding episodes. Results Forty-four males were included; mean age was 1 year ± 1.7 years at presentation. Mean period of follow-up was 7.9 ± 3.6 years. The most common complaints at presentation were muscle bleeds (29.5%) and post-circumcision bleeding (11.4%). Two (4.5%) had mild HA, 29 (66%) had moderate HA, and 13 (29.5%) had severe HA. Twenty-eight (63.6%) were on regular prophylaxis, ten (22.7%) developed at least one target joint, and six (13.6%) developed FVIII inhibitors. The mean annualised bleeding rate was 1.8 ± 2.3, 4.6 ± 0.4, and 4.6 ± 8.6 for the persons with mild, moderate, and severe HA, respectively. Conclusion The clinical phenotype of Omani children is milder compared to other studies but with similar clinical outcomes.