Palmoplantar epidermal differentiation disorders: a new classification toward pathogenesis-based therapy
More than 50 palmoplantar epidermal differentiation disorders (pEDDs) have been reported in the literature. Various descriptors have been used to name these conditions, including clinical features often designated as acronyms or evocative terms, and names of clinicians and of geographical locations. Not only has this nomenclature been criticized for its lack of methodological consistency, but it has also progressively lost its clinical relevance. Indeed, the advent of a wide range of pathogenesis-targeting therapeutic solutions for these disorders has raised the need for a novel classification of pEDDs, based on their causative genetic defects, to provide clinicians with genuine therapeutic guidance. Here, we present a novel classification scheme for pEDDs and its application in the form of a practical algorithm for the rapid diagnosis of pEDDs.
Authors
- Á. Hernández‐Martín (ORCID: https://orcid.org/0000-0001-7260-8718)
- Joyce Teng (ORCID: https://orcid.org/0000-0002-1633-6807)
- Alain Hovnanian (ORCID: https://orcid.org/0000-0003-3412-7512)
- Amy S. Paller (ORCID: https://orcid.org/0000-0001-6187-6549)
- Janice Schwartz (ORCID: https://orcid.org/0000-0002-7676-2082)
- Gianluca Tadini (ORCID: https://orcid.org/0000-0003-1164-2802)
- Judith Fischer (ORCID: https://orcid.org/0000-0003-0398-7720)
- Eli Sprecher (ORCID: https://orcid.org/0000-0002-4093-1032)
- Kiril Malovitski (ORCID: https://orcid.org/0000-0002-4171-6668)
- Akemi Ishida‐Yamamoto (ORCID: https://orcid.org/0000-0002-3104-102X)
- J. Mazereeuw‐Hautier (ORCID: https://orcid.org/0000-0001-6259-9790)
- Keith A. Choate (ORCID: https://orcid.org/0000-0003-1010-6354)
- Matthias Schmuth (ORCID: https://orcid.org/0000-0002-4064-1334)
- Antoni Gostyński (ORCID: https://orcid.org/0000-0002-1091-2914)
- Céline Granier Tournier (ORCID: https://orcid.org/0000-0002-6274-0341)
- Edel A. O’Toole (ORCID: https://orcid.org/0000-0002-4084-4836)
- Masashi Akiyama (ORCID: https://orcid.org/0000-0001-5863-9315)
- Christine Bodemer (ORCID: https://orcid.org/0000-0002-3089-5744)
- Mandy Aldwin-Easton
Institutions
- Northwestern University (US)
- Hôpital Necker-Enfants Malades (FR)
- Lurie Children's Hospital (US)
- Université Toulouse III - Paul Sabatier (FR)
- Asahikawa Medical University (JP)
- Inserm (FR)
- University of Freiburg (DE)
- Tel Aviv University (IL)
- Queen Mary University of London (GB)
- University of Milan (IT)
- Université Paris Cité (FR)
- Tel Aviv Sourasky Medical Center (IL)
- University Medical Center Freiburg (DE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Yale University (US)
- Maastricht University (NL)
- Institut Necker Enfants Malades (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospital Infantil Universitario Niño Jesús (ES)
- Karl Landsteiner Society (AT)
- Institut des Maladies Génétiques Imagine (FR)
- Pachyonychia Congenita Project (US)
- Nagoya University (JP)
- Stanford University (US)
Publication Details
- Journal
- British Journal of Dermatology
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1093/bjd/ljaf054
- Citations
- 21
- Primary Topic
- Nail Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 28.44