New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma
sCSF-1R<sub>M149K</sub>-Fc efficiently traps both CSF-1 and IL-34 and inhibits CSF-1R signaling, monocyte survival and suppressive macrophage differentiation induced by pleural mesothelioma cells producing CSF-1 and IL-34, as well as restores cytotoxic T-cell responses. sCSF-1R<sub>M149K</sub>-Fc has therapeutic potential vs other therapies under development targeting single components of this complex cytokine pathway involved in cancer.
Authors
- Romain Humeau
- Carole Guillonneau (ORCID: https://orcid.org/0000-0002-7195-0631)
- Noémie Joalland (ORCID: https://orcid.org/0000-0002-1620-6658)
- Erwan Mortier (ORCID: https://orcid.org/0000-0002-6321-6488)
- Sophie Deshayes
- Christophe Blanquart (ORCID: https://orcid.org/0000-0002-0917-3747)
- Agnès Quéméner (ORCID: https://orcid.org/0000-0002-4026-8496)
- Judith Fresquet
- Apolline Salama (ORCID: https://orcid.org/0000-0002-3157-0749)
- Séverine Remy (ORCID: https://orcid.org/0000-0002-5241-880X)
- Ignacio Anegón (ORCID: https://orcid.org/0000-0001-8700-5645)
- Mike Maillasson (ORCID: https://orcid.org/0000-0001-9526-7880)
- Héloïse LeBihan
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR)
- Nantes Université (FR)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/jitc-2024-010112
- Citations
- 4
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Infrastructures en Biologie Santé et Agronomie
- Agence Nationale de la Recherche
- Fondation ARC pour la Recherche sur le Cancer
- Ligue Contre le Cancer
- Labex