Cost Effectiveness of Prophylactic Mastectomy and Autologous Flap Reconstruction in BRCA1/2-Positive Patients
Prophylactic mastectomy with autologous reconstruction performed at ages 30, 35 or 40 years, was found to be a cost-effective alternative to breast cancer surveillance and disease treatment in women with BRCA1/2 mutations. DIEP and free transverse rectus abdominis myocutaneous flaps were the most cost-effective techniques, and prophylaxis was more cost effective in BRCA1 patients than in BRCA2 patients.
Authors
- Reid W. Smith (ORCID: https://orcid.org/0009-0009-4121-9301)
- Clifford C. Sheckter (ORCID: https://orcid.org/0000-0002-9526-4062)
- Sneha Subramaniam (ORCID: https://orcid.org/0000-0002-5688-7291)
- Neil Tanna (ORCID: https://orcid.org/0000-0002-4678-6016)
- Isabelle T. Smith (ORCID: https://orcid.org/0009-0005-1907-0812)
- Michael L. Smith (ORCID: https://orcid.org/0000-0003-3757-2726)
- Jagmeet S. Arora
Institutions
- University of California, Irvine (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Plastic & Reconstructive Surgery
- Published
- 2025-03-14
- DOI
- https://doi.org/10.1097/prs.0000000000012094
- Citations
- 2
- Primary Topic
- Biomedical Ethics and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.33