Molecular docking analysis of phytochemicals from Soothaga Thadai Kudineer with cyp-17α-hydroxylase enzyme

Polycystic ovarian syndrome (PCOS) affects 9.2% of women of reproductive age and has doubled in prevalence, rising from 6 million cases in 1990 to 12.13 million in 2019. PCOS is characterized by symptoms like irregular periods, acne, hirsutism, male-pattern baldness, weight gain, mood swings and infertility. PCOS is primarily associated with elevated androgen levels. The use of Indian <i>Soothaga Thadai Kudineer</i> for managing PCOS is well documented. Therefore, it is of interest to report the <i>Molecular docking</i> analysis of phytochemicals from Indian <i>Soothaga Thadai Kudineer</i> with cyp-17α-hydroxylase enzyme (CYP17). Analysis shows that phytochemicals such as gingerenone A, chlorogenic acid and piperine present in <i>Soothaga Thadai Kudineer</i> exhibit strong binding affinities to the enzyme suggesting their potential as CYP17 inhibitors for further validation and consideration.