Loss of epe1+ extends chronological lifespan in Schizosaccharomyces pombe

Aging is a complex phenomenon that is characterized by the altered regulation of various biological processes over time. One of these, epigenetics, play a crucial role throughout the different stages of eukaryotic life and its alteration is considered a key molecular hallmark of aging. However, the epigenetic factors which are important for lifespan control remain elusive. Here, we used <i>S. pombe</i> as a model organism to study the epigenetic basis of aging. Our study reveals that loss of the <i>epe1</i> + gene, encoding for the JmjC domain protein Epe1 , extends chronological lifespan and increases H3K9me3 in aged <i>S. pombe</i> cells <i>.</i>