[Impact of hemodynamic pattern of non-culprit vessel stenosis on the long-term prognosis in patients with acute ST-segment elevation myocardial infarction].

<b>Objective:</b> To investigate the correlation between the hemodynamic pattern of non-culprit vessel stenosis and long-term vessel-oriented composite outcome(VOCO) in patients with acute ST-segment elevation myocardial infarction (STEMI). <b>Methods:</b> From January 2019 to December 2021, 233 consecutive patients with STEMI and non-culprit vessel stenosis were prospectively enrolled at Shanghai East Hospital. The median follow-up duration was 3.9 years. The 367 non-culprit vessels of the 233 patients were divided into the VOCO group (33 vessels, 9.0%) and the non-VOCO group (334 vessels, 91.0%). Parameters pertaining to the hemodynamic pattern of non-culprit vessel stenosis between the two groups were compared. Receiver operating characteristic (ROC) curves were used to assess the correlation between hemodynamic pattern and VOCO, and Cox multivariate regression and logistic multivariate regression analyses were applied to identify independent predictors of VOCO. <b>Results:</b> The 233 enrolled patients were aged (62.5±12.9) years, with 193 males (82.8%). In the VOCO group, the maximum quantitative flow ratio (QFR) decreased within 20 mm of the QFR-assessed segment, the difference in QFR across the entire vessel, the length of functionally significant vessel, and the maximum gradient of QFR decrease (dQFR/dsmax) were significantly greater than those in the non-VOCO group. ROC curve analysis showed that the optimal threshold for predicting VOCO using dQFR/dsmax was 0.009 6 (area under the curve: 0.691, 95%<i>CI</i>: 0.606-0.775, <i>P</i><0.001). Multivariable Cox regression analysis revealed that dQFR/dsmax was an independent predictor of VOCO (<i>HR</i>=1.199, 95%<i>CI</i>: 1.070-1.343, <i>P</i>=0.002). When anatomical and functional stenosis severities were included in the model, a high pullback pressure gradient (PPG) index (<i>HR</i>=1.572, 95%<i>CI:</i> 1.052-2.351, <i>P</i>=0.027) emerged as an independent predictor of VOCO. Multivariable logistic regression analysis revealed that a low PPG index(<i>OR</i>=2.851, 95%<i>CI</i>: 1.945-4.178, <i>P</i><0.001) was an independent predictor of QFR≤0.80 without long-term VOCO. <b>Conclusion:</b> In patients with STEMI, localized hemodynamic patterns of coronary artery stenosis, characterized by high dQFR/dsmax and high PPG index, are associated with long-term VOCO.