Single‐cell RNA sequencing of peripheral blood mononuclear cells from bronchopulmonary dysplasia
Single-cell sequencing revealed immune cell profiles in bronchopulmonary dysplasia (BPD). Neutrophils underwent metabolic changes, and B cells were key in immune communication. Targeting B and T lymphocyte attenuator (BTLA)-TNFRSF14 signalling reduced BPD severity in mouse models, suggesting a potential therapy.
Authors
- Chun Yan
- Wangkai Liu (ORCID: https://orcid.org/0000-0001-8649-888X)
- Sitao Li (ORCID: https://orcid.org/0000-0002-4035-8635)
- Xiaoyu Lin
- Yufeng Liu (ORCID: https://orcid.org/0009-0002-4794-3316)
- Yanfang Tan (ORCID: https://orcid.org/0000-0001-8025-4067)
- Yushan Li (ORCID: https://orcid.org/0009-0005-0468-0589)
- Limei Zhong
- Qiong Meng (ORCID: https://orcid.org/0000-0002-6734-4743)
- Ruoxing Zhou
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou First People's Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Province Women and Children Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Children's Hospital of Fudan University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/ctm2.70276
- Citations
- 3
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56