Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells
Collectively, this study revealed that Mdivi.1 downregulates Drp1, upregulates Mfn2, and increases mitochondrial mass with attenuated oxidative metabolism, leading to the inhibition of cell invasion and metastasis in colorectal cancer HCT116 cells. Mitochondrial dynamics are regarded as possible drug targets for interrupting colorectal cancer cell migration and metastasis.
Authors
- Tahir Mehmood (ORCID: https://orcid.org/0000-0002-6445-455X)
- Chatchai Muanprasat (ORCID: https://orcid.org/0000-0001-6849-6637)
- Qandeel Nasir
- Iqra Younis
Institutions
- Superior University (PK)
- Ramathibodi Hospital (TH)
Publication Details
- Journal
- Journal of Experimental Pharmacology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/jep.s510578
- Citations
- 4
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Mahidol University