Novel protocol for metabolomics data normalization and biomarker discovery in human tears
This novel normalization protocol significantly improves the reliability of tear metabolomics by enabling standardized interindividual comparisons. The approach facilitates biomarker discovery by mitigating variability in metabolite concentrations and may be extended to other biological fluids, enhancing its applicability in precision medicine.
Authors
- Joan Serrano‐Marín (ORCID: https://orcid.org/0000-0001-9316-0721)
- Silvia Marín (ORCID: https://orcid.org/0000-0003-0693-2207)
- Alberto Alvarez‐Iglesias (ORCID: https://orcid.org/0000-0001-5011-9008)
- Juan Sánchez-Navés
- Rafael Franco (ORCID: https://orcid.org/0000-0003-2549-4919)
- David Bernal‐Casas (ORCID: https://orcid.org/0000-0002-4623-5935)
- Hanan Awad Alkozi (ORCID: https://orcid.org/0000-0002-7452-9287)
- Irene Reyes‐Resina (ORCID: https://orcid.org/0000-0003-2077-2537)
- Marta Cascante (ORCID: https://orcid.org/0000-0002-2062-4633)
- Jaume Lillo (ORCID: https://orcid.org/0000-0001-7712-0850)
- Claudia Garrigós (ORCID: https://orcid.org/0009-0001-7296-949X)
- Toni Capó (ORCID: https://orcid.org/0009-0007-4716-5020)
Institutions
- Qassim University (SA)
- Instituto de Salud Carlos III (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1515/cclm-2024-1360
- Citations
- 2
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 3.76