Targeting DNA Topoisomerase IIα in Retinoblastoma: Implications in EMT and Therapeutic Strategies
TOP2A is pivotal in RB pathogenesis and progression, primarily by regulating EMT. Its inhibition not only curtails RB cell proliferation and metastasis but also reverses EMT, underscoring its potential as a therapeutic target. This study lays the groundwork for further exploration of TOP2A-targeted therapies in RB.
Authors
- Nan Lin (ORCID: https://orcid.org/0000-0003-0083-6804)
- Qingquan Wei
- Li Ping Wang (ORCID: https://orcid.org/0000-0001-6893-3809)
Institutions
- Shanghai Jiao Tong University (CN)
- Tongren Hospital (CN)
Publication Details
- Journal
- Biologics
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/btt.s499314
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission