Risk Factors Associated with MDR and CR Acinetobacter baumannii Carriage among ICU Patients Hospitalized at Hospitals in Pakistan

Background: In hospital intensive care units (ICUs) around the world, multidrug-resistant and carbapenem-resistant Acinetobacter baumannii (CRAB) infections pose a serious concern, and this is especially true in developing nations like Pakistan. There is insufficient comprehensive evidence on the parameters linked to MDR and CR Acinetobacter baumannii carriage among hospitalized intensive care unit (ICU) patients, despite the limited treatment choices. In order to close this gap, our study identified risk variables for MDR and CR Acinetobacter baumannii carriage in intensive care unit patients at Police Services Hospital and Holy Family Hospital in Pakistan. Methods: Between July 2019 and July 2020, 132 ICU-admitted patients were purposefully enrolled in this study using a cross-sectional study design. Using a standardized questionnaire, demographic data and risk variables related to MDR and CR Acinobacter baumannii were gathered. The data was analyzed using bivalent analysis and descriptive statistics. For every analysis, the 95% confidence interval (CI) was the level of statistical significance. Results: Employed participants had a 3.4-fold higher risk of having A. baumannii than jobless participants, according to bivariable analysis (cOR = 3.38, 95%, CI: 1.09 - 10.43, p = 0.035). Compared to patients with normal or low BMI, individuals with high BMI had a higher chance of contracting A. baumannii (aOR = 11.2, 95%, CI: 3.57 - 21.11, p = 0.004). The likelihood of having carbapenem-resistant Acinetobacter baumannii was 21 times higher in those over 50 (COR = 21.0, 95% CI: 1.83 - 240.52, p = 0.011). Carbapenem-resistant Acinetobacter baumannii was 16 times more common in patients who remained in the intensive care unit (ICU) for longer than 30 days than in those who had been hospitalized (COR = 16.0, 95% CI: 1.45 - 176.45, p = 0.019). Conclusion: Among patients admitted to intensive care units, A. baumannii infections were shown to be substantially correlated ...