Campthothecin as inhibitor of liprin alpha-2 for management of Breast cancer

Liprin alpha 2 protein which is present in body is responsible for breast cancer by increasing the cell motility of cancerous cells. In earlier studies some fungal pigments are used to inhibit the function of liprin protein and used for curing breast cancer. Now by following the approach of docking an alkaloid (campthothecin) is expected for showing some useful results against this protein. For this we take protein structure from protein data bank and take ligand (campthothecin) from zinc data base. Docking of ligand-protein was done by using Swiss docking and score is checked of this docking result by DSX scoring. The resulting energy of this docking is -7.27 which shows that it has some effective effects against liprin action. These results cleared that this ligand may be expected drug to cure hormone dependent breast cancer.