Development and Characterization of LasR Immobilized Monolithic Column for Screening Active Ingredients as Quorum Sensing Inhibitors Against P. aeruginosa in Natural Products
The proposed LasR immobilized monolithic column is a viable strategy in screening LasR inhibitors. It can be considered as a possible alternative to traditional methods for screening LasR inhibitors as drug candidates against <i>P. aeruginosa</i>.
Authors
- Jialiang Guo (ORCID: https://orcid.org/0009-0003-9651-8129)
- Jiangying You
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0002-7596-7406)
- Zheng Liu (ORCID: https://orcid.org/0000-0003-4158-6768)
- Rui Li (ORCID: https://orcid.org/0000-0002-0907-4941)
- Xiaoyuan Xie (ORCID: https://orcid.org/0000-0003-2828-7165)
- Yue Yang (ORCID: https://orcid.org/0000-0003-2188-6077)
- Xianglong Zhao
Institutions
- Foshan University (CN)
- Jinan University (CN)
- Key Laboratory of Guangdong Province (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-03-01
- DOI
- https://doi.org/10.2147/dddt.s501621
- Citations
- 2
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Guangdong Medical Research Foundation