Clozapine-induced obsessive-compulsive symptoms in schizophrenia: Clinical and cognitive determinants of dysfunctional checking
This study is the first to compare the distinct cognitive and clinical profiles of SCZ-OCS, SCZ-only, and OCD, with a focus on checking behavior, a major symptom in clozapine-treated patients. We introduced a novel and sensitive measure for checking, which showed dysfunctional checking only in SCZ-OCS patients treated with clozapine. These findings indicate that a subset of patients with schizophrenia with more severe positive symptoms and cognitive deficits are especially susceptible to OCD symptoms when treated with clozapine.
Authors
- Isaac Jarratt Barnham (ORCID: https://orcid.org/0000-0002-3875-0881)
- Núria Segarra (ORCID: https://orcid.org/0000-0001-9909-7751)
- Emilio Fernández-Egea (ORCID: https://orcid.org/0000-0003-4128-8955)
- Marjan Biria (ORCID: https://orcid.org/0000-0003-2671-0150)
- Aleya A. Marzuki (ORCID: https://orcid.org/0000-0002-8497-7112)
- Qiang Luo (ORCID: https://orcid.org/0000-0002-0426-6039)
- Engin Keser (ORCID: https://orcid.org/0009-0001-8100-688X)
- Maria Daniela Farrugia
- Naomi Fineberg (ORCID: https://orcid.org/0000-0003-1158-6900)
- Trevor William Robbins (ORCID: https://orcid.org/0000-0003-0642-5977)
- Paula Banca (ORCID: https://orcid.org/0000-0001-7617-3635)
- Akeem Sule
Institutions
- King's College London (GB)
- University of Cambridge (GB)
- Hertfordshire Partnership University NHS Foundation Trust (GB)
- University of Oxford (GB)
- Cambridgeshire and Peterborough NHS Foundation Trust (GB)
- German Center for Diabetes Research (DE)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
- University College London (GB)
- University of Tübingen (DE)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/s0033291724003350
- Citations
- 4
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.23
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Oxford
- National Natural Science Foundation of China
- Medical Research Council
- National Key Research and Development Program of China
- Program of Shanghai Academic Research Leader
- NIHR Cambridge Biomedical Research Centre