Aptamer‐Directed Bidirectional Modulation of Vascular Niches for Promoted Regeneration of Segmental Trachea Defect (Adv. Funct. Mater. 12/2025)
Tissue-Specific Aptamer Matrices In article number 2409071, Dong Xie, Deping Zhao, Yong Hu, Chang Chen, and co-workers successfully engineer a biomimetic trachea with regenerated vascular connective tissue scattered between avascular cartilage rings using the assembly of two distinct tissue-specific aptamer matrices. This approach fosters the development of (a)vascular niches in reconstructed trachea after end-to-end anastomosis, along with optimal structural, mechanical, and physiological features.
Authors
- Zhenying Chen (ORCID: https://orcid.org/0000-0002-9135-3535)
- Deping Zhao (ORCID: https://orcid.org/0000-0003-0109-5171)
- Yulong Hu (ORCID: https://orcid.org/0000-0003-3844-3950)
- Weikang Lin (ORCID: https://orcid.org/0000-0003-4164-4171)
- Yong Ming Hu (ORCID: https://orcid.org/0000-0003-1425-6093)
- Qingfeng Bai
- Qing Ye (ORCID: https://orcid.org/0000-0003-3927-1919)
- Junhao Liang (ORCID: https://orcid.org/0000-0001-5612-7631)
- Yi Chen (ORCID: https://orcid.org/0000-0001-5329-4987)
- Chang Chen (ORCID: https://orcid.org/0000-0002-9981-3110)
- Dong Xie (ORCID: https://orcid.org/0000-0002-3715-1801)
- Z. Pan (ORCID: https://orcid.org/0009-0009-8534-0875)
- Hai Tang (ORCID: https://orcid.org/0000-0002-7344-6041)
- Xiuchun Yang
- Runfeng Cao
- Weiyan Sun (ORCID: https://orcid.org/0000-0001-5476-280X)
- Lei Wang (ORCID: https://orcid.org/0000-0003-0734-7026)
Institutions
- Tongji University (CN)
- Fudan University (CN)
- Zhongda Hospital Southeast University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- Advanced Functional Materials
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1002/adfm.202570068
- Citations
- 2
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.04