Total synthesis of breviscapin B <i>via</i> intramolecular dehydrative etherification
The total synthesis of breviscapin B, a norlignan natural product having an unusual 2,2-diaryltetrahydrofuran skeleton, has been achieved <i>via</i> intramolecular dehydrative Williamson ether synthesis as a key step. The use of a combination of <i>p</i>-TsOH·H<sub>2</sub>O and polyfluorinated alcohol was found as an effective method for the synthesis of 2-aryl-substituted saturated oxygen heterocycles.
Authors
- Masahiro Anada (ORCID: https://orcid.org/0000-0002-7691-5114)
- Shunsuke Sueki (ORCID: https://orcid.org/0000-0003-0951-0018)
- Kosho Makino (ORCID: https://orcid.org/0000-0001-8635-6793)
- Chiharu Nogami
Institutions
- Musashino University (JP)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00350d
- Citations
- 3
- Primary Topic
- Traditional and Medicinal Uses of Annonaceae
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Musashino University
- Japan Society for the Promotion of Science