Rapidly Progressive Pancreatitis with Multi-Organ Failure: A Severe Sequela of COVID-19

Acute pancreatitis (AP) is a leading cause of gastrointestinal hospitalizations, with gallstones and alcohol being the most common etiologies. Although viral infections have been implicated in pancreatitis, the association between COVID-19 and pancreatic inflammation remains under investigation. We present a case of a 67-year-old male with no prior history of pancreatitis who developed severe AP with multi-organ failure following a SARS-CoV-2 infection. The patient experienced acute epigastric pain, nausea, and vomiting, with laboratory findings showing significantly elevated lipase levels, acute kidney injury, and transaminitis. Imaging revealed extensive pancreatic necrosis. Despite intensive supportive care, the patient progressed to septic shock, acute respiratory distress syndrome (ARDS), and ultimately fatal multi-organ dysfunction. This case underscores the potential for COVID-19 to contribute to severe pancreatic inflammation and systemic complications. Increased awareness of this association may help facilitate early recognition and management of similar cases.