The Influence of Vitamins D and K on Some Biochemical, Cytochemical, and Clinical Blood Parameters In Vivo with Separate and Combined Administration

A comprehensive study was conducted on the effect of vitamins D and K on some indicators of lipid peroxidation and the overall antioxidant activity of blood plasma in rats of two age groups. Differences in the studied parameters were revealed both in terms of age and under the influence of administered vitamins. An antioxidant effect of vitamin D is noted in adult animals, which is expressed in a significant decrease in the level of malondialdehyde (MDA) in blood plasma. In young people, a similar effect was found with the combined action of vitamins D and K. The content of lipids, glycogen, and cationic proteins in blood neutrophils of animals receiving vitamins D and K separately and together was analyzed. Significant changes in the content of cationic proteins were revealed when vitamin K was administered to adult animals. When analyzing the leukocyte formula, vitamin K and a complex of vitamins D and K showed the greatest effect, reflected in a change in the proportion of monocytes and lymphocytes. A negative correlation was shown between the lipid content in blood neutrophils and the level of one of the lipid peroxidation products, MDA, in blood plasma.