Elucidating the critical role of gut microbiota in the pathogenesis of bacterial pneumonia: insights from a Mendelian randomization analysis mediated by immune cell
The study identified specific components of the GM that confer a protective effect against BP. It revealed that the subsets of HLA DR + Natural Killer %CD3- lymphocytes are modulated by Clostridia, thereby enhancing the host's immune defense against BP.
Authors
- Lianyi Han (ORCID: https://orcid.org/0000-0002-6364-7843)
- Bin Pan (ORCID: https://orcid.org/0000-0002-5134-2508)
- Wang Chang-le (ORCID: https://orcid.org/0000-0001-8559-7923)
- Dongmei Yu (ORCID: https://orcid.org/0000-0001-7901-4365)
- Song Guo Zheng (ORCID: https://orcid.org/0000-0002-5611-4774)
- Zhipeng Meng (ORCID: https://orcid.org/0000-0003-4756-6303)
- Yawen Liu (ORCID: https://orcid.org/0000-0002-9500-7373)
- Shuo Yuan (ORCID: https://orcid.org/0000-0002-6455-194X)
- Xin Gao (ORCID: https://orcid.org/0000-0002-7383-6453)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12879-025-10758-0
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Health Commission of Hebei Province