Wnt5a augments intracellular free cholesterol levels and promotes castration resistance in prostate cancer
The findings of this study highlight a novel molecular mechanism underlying endocrine therapy resistance in CRPC mediated by Wnt5a. Targeting Wnt5a or reducing cholesterol level would be a promising therapeutic strategy for the treatment of CRPC, providing new insights into potential avenues for combating this challenging form of prostate cancer.
Authors
- Yujing Gao (ORCID: https://orcid.org/0000-0003-0718-4992)
- Lintao Dong
- Yuqi Guo (ORCID: https://orcid.org/0000-0002-7060-8404)
- Zhiyuan Zhang (ORCID: https://orcid.org/0000-0003-3845-7420)
- Xiaohan Li (ORCID: https://orcid.org/0000-0003-4786-0190)
- Mingxiu Luo
- Yajuan Fu (ORCID: https://orcid.org/0000-0001-6224-8579)
- Xinyi Shi (ORCID: https://orcid.org/0009-0005-3807-3322)
Institutions
- Ningxia Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12967-025-06322-8
- Citations
- 3
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningxia Province