Synthesis of Chromanes by Triflimide-Catalyzed Annulations of Benzylic Alcohols and Alkenes
The convergent synthesis of a series of chromane derivatives by a triflimide-catalyzed annulation of <i>o</i>-hydroxy benzylic alcohols with alkenes is reported. The Brønsted acid-catalyzed reaction proceeds from simple starting materials under mild conditions and provides chromane products of varying substitution patterns.
Authors
- Rebekah G. Reynolds (ORCID: https://orcid.org/0000-0002-8723-2749)
- Martin B. Jones
- Regan J. Thomson (ORCID: https://orcid.org/0000-0001-5546-4038)
- Kalli G. Koukounas
- Jingyi Luo (ORCID: https://orcid.org/0000-0003-2988-1465)
- Weiwei Wang (ORCID: https://orcid.org/0000-0003-0333-0868)
- Maria D. Guerrero (ORCID: https://orcid.org/0009-0003-5403-2876)
- Kayla G. Eichmann
Institutions
- Northwestern University (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1021/acs.joc.5c00160
- Primary Topic
- Synthesis of Indole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Northwestern University
- National Institutes of Health