Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models
Excessive type I interferons during pregnancy are associated with poor pregnancy outcomes. Ding et al.<sup>1</sup> demonstrate the pathogenic effects of the interferon-stimulated gene RSAD2 that drives adverse pregnancy outcomes through placental lipid accumulation, and further identify a promising therapeutic candidate.
Authors
- Kellie A. Jurado (ORCID: https://orcid.org/0000-0003-0466-2696)
- Seble G. Negatu
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Cell Reports Medicine
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.xcrm.2025.102034
- Citations
- 2
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.59