Stromal Cell Subsets Show Model-Dependent Changes in Experimental Colitis and Affect Epithelial Tissue Repair and Immune Cell Activation
The relative abundance changes of stromal cell subsets during experimental colitis differ between 3 established colitis models. Treatment with IBD therapies influences stromal subset abundance, indicating their importance in IBD pathogenesis, possibly through affecting epithelial migration, and T-cell activation.
Authors
- Lei Brands
- Eveline S. M. de Jonge‐Muller
- Bram W. van Os (ORCID: https://orcid.org/0000-0002-2327-0527)
- Andrea E. van der Meulen‐de Jong (ORCID: https://orcid.org/0000-0001-9353-5431)
- Marieke C. Barnhoorn (ORCID: https://orcid.org/0000-0002-5298-1117)
- Lukas J.A.C. Hawinkels (ORCID: https://orcid.org/0000-0002-2274-9325)
- Stef G. Janson
- Leonie G Plug
- Zhou Zhou (ORCID: https://orcid.org/0000-0001-5914-1340)
- L. M van Beek
- Jie Su (ORCID: https://orcid.org/0000-0002-5504-1868)
Institutions
- Leiden University Medical Center (NL)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1093/ibd/izae255
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- China Scholarship Council