A Comparative Study of the Effects of Hybrid and Hyaluronic Acid Fillers on Secondary Intention Wound Healing

Aims: To compare the effects of Hybrid filler (hyaluronic acid + calcium hydroxylapatite) and hyaluronic acid filler (HA) on skin healing after induced wounds using histological analysis. Materials and Methods: Three groups of three male Albino rats were randomly placed in the 3rd, 7th, and 14th repair times. Rats have three circular cuts on their backs. The top wound got hybrid filler (NEAUVIA STIMULATE®), the bottom right wound got hyaluronic acid filler (TEOSYAL RHA® 3), and the bottom left wound wasn't filled as a test. On days 3, 7, and 14, biopsies were taken from each rat and sent to a pathologist for histopathology. Results: The treated groups showed less inflammation than the control group, especially on the third and seventh days. On the fourteenth day, the tested groups had much lower granulation tissue production rates than the control group, which stayed high. On day 14, the hybrid filler group had the most re-epithelialization. Conclusion: The skin of rats healed faster with hybrid and HA fillers. They may help wounds heal.