Genetic analysis of uterine lavage fluids to identify women at high risk of endometrial cancer
Our findings did not confirm a direct association between specific genetic mutations in uterine lavage fluid and the presence of EIN or early-stage EC (p = 0.501). Mutations were detected in both cases and controls, with a higher overall mutation burden observed in controls, suggesting potential background genomic alterations unrelated to EC development. In conclusion, while molecular profiling of uterine lavage fluid remains a promising concept for non-invasive diagnosis, our results highlight significant challenges in specificity. Further studies with larger cohorts and additional biomarkers are necessary to clarify its diagnostic relevance and clinical applicability.
Authors
- Tamara Kolářová
- Filip Zavadil-Kokas
- Jitka Hausnerová (ORCID: https://orcid.org/0000-0002-0522-1916)
- Lucie Mouková
- Roman Hrstka (ORCID: https://orcid.org/0000-0002-6139-2664)
- Petra Ovesná (ORCID: https://orcid.org/0000-0002-3547-5896)
- Vít Weinberger (ORCID: https://orcid.org/0000-0003-4858-1951)
- Markéta Bednaříková (ORCID: https://orcid.org/0000-0003-3189-7028)
- Luboš Minář (ORCID: https://orcid.org/0000-0001-9088-5428)
- Petra Bretová (ORCID: https://orcid.org/0000-0003-1082-433X)
- Dita Münzová
- Maryam Shahidianakbar
- Milan Anton
Institutions
- Masaryk University (CZ)
- University Hospital Brno (CZ)
- Masaryk Memorial Cancer Institute (CZ)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13104-025-07173-8
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy
- Ministerstvo Zdravotnictví Ceské Republiky
- Agentura Pro Zdravotnický Výzkum České Republiky