Clinical efficacy of Holisal gel as part of complex conservative treatment of patients with inflammatory periodontal diseases

Aim. To study the analgesic, anti-inflammatory and antimicrobial properties of Holisal gel when used for conservative treatment of patients with gingivitis and periodontitis. Material and methods. A comprehensive dental examination and treatment of 40 patients aged 25 to 54 years without severe somatic pathology was conducted. The first group included 20 people diagnosed with chronic gingivitis, the second group – 20 patients with mild periodontitis. As part of the comprehensive conservative treatment in both groups, the dental gel Holisal was used. To assess the analgesic effect of the Holisal gel, patients were surveyed before and after its single use at a dental appointment. Pain was assessed using a verbal scale. To assess the effectiveness of the treatment course, a dental examination of patients with an index assessment of the condition of periodontal tissues and a PCR study of subgingival microflora were performed, comparing the indicators before treatment and 10 days after the start of treatment. Results. A survey of patients showed that 10 minutes after a single application of Holisal gel by a dentist after professional oral hygiene, a pronounced analgesic effect was noted: the absence of pain was reported by 17 (85.0%) patients in the first group and 15 (75.0%) in the second group. During a course of treatment with Holisal gel, 10 days after the start of treatment, patients with gingivitis showed a statistically significant decrease in the Green–Vermillion hygiene index by 72.0% (<0.001), and the Muhlemann–Cowell bleeding index by 67.3% (p<0.001). In patients with periodontitis, the hygiene index decreased by 64.6% (p<0.001), the Muhlemann–Cowell bleeding index by 67.8% (p<0.001), and a statistically significant decrease in the depth of periodontal pockets was observed (from 2.1±0.2 mm to 1.3±0.2 mm, p<0.05). PCR testing of subgingival microflora showed that the use of Holisal gel as part of complex therapy contributed to the complete elimination of periodontopathogenic microflora in patients with gingivitis. In patients with periodontitis, after completion of the treatment, there was a significant decrease in the frequency of detection of such representatives of anaerobic microflora as Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, while the rest of the studied periodontopathogens were not detected after treatment. Conclusions. The use of Holisal gel in patients with gingivitis and mild periodontitis demonstrated a pronounced analgesic effect after a single application, as well as anti-inflammatory and antimicrobial efficacy after a 10-day course of complex conservative therapy.