Bone Marrow CD34+/lin− Cells of Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) After 12 Months of Nilotinib Treatment Exhibit a Different Gene Expression Signature Compared to the Diagnosis and the Corresponding Cells from Healthy Subj
We observed that certain transcriptome features present at diagnosis persisted after 12 months of nilotinib treatment, compared to CTRLs. This suggests that nilotinib may exert selective pressure, potentially supporting the survival and self-renewal of LSCs. Future insights into these pathways could help identify therapeutic targets to improve outcomes in CML.
Authors
- Mauro Turrini (ORCID: https://orcid.org/0000-0001-5299-8456)
- Ester Pungolino (ORCID: https://orcid.org/0000-0003-0318-6616)
- Michela Anghilieri
- Alessandro Beghini (ORCID: https://orcid.org/0000-0002-8234-3474)
- Alessandra Iurlo (ORCID: https://orcid.org/0000-0002-4401-0812)
- Salvatore Artale
- Maria Cristina Carraro
- Cristina Bucelli (ORCID: https://orcid.org/0000-0002-5631-3634)
- Roberto Cairoli (ORCID: https://orcid.org/0000-0001-6372-2623)
- Chiara Elena (ORCID: https://orcid.org/0000-0002-0058-7142)
- Simona Malato
- Maria Luisa Latargia
- Pierangelo Spedini
- Alessandra Perego
- Alessandra Trojani (ORCID: https://orcid.org/0000-0002-7659-2968)
- Francesco Spina
- Barbara Di Camillo (ORCID: https://orcid.org/0000-0001-8415-4688)
- Luca Emanuele Bossi (ORCID: https://orcid.org/0000-0001-6409-8391)
- Cassandra Palumbo (ORCID: https://orcid.org/0000-0003-3677-0499)
- Lorenza Borin
- Mariella D’Adda
Institutions
- University of Padua (IT)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Ospedale di Circolo di Busto Arsizio (IT)
- Policlinico San Matteo Fondazione (IT)
- Azienda Ospedaliera di Desio e Vimercate (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- ASST Fatebenefratelli Sacco (IT)
- Ospedale Valduce (IT)
- Istituti Ospitalieri di Cremona (IT)
- Azienda Socio Sanitaria Territoriale di Cremona
Publication Details
- Journal
- Cancers
- Published
- 2025-03-18
- DOI
- https://doi.org/10.3390/cancers17061022
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00