Large-Scale Multiomic Analysis Identifies Anatomic Differences and Immunogenic Potential in Subtypes of Leiomyosarcoma
Comprehensive profiling suggested that uLMS represents a molecularly distinct disease from non-uLMS. Although traditional ICI response biomarkers were similar across anatomic subtypes, uLMSs were immune cold compared with non-uLMS. Signals for ICI responsiveness, such as high TIS and immune cell abundance, in some tumors suggest that further research into immunotherapies for LMS is warranted.
Authors
- Jonathan C. Trent (ORCID: https://orcid.org/0000-0001-6169-5238)
- Alexander J. Chou (ORCID: https://orcid.org/0000-0002-7926-3326)
- Abhijeet Kumar (ORCID: https://orcid.org/0000-0002-6990-4775)
- Jaime F. Modiano (ORCID: https://orcid.org/0000-0001-6398-7648)
- Andrea P. Espejo Freire (ORCID: https://orcid.org/0000-0001-9903-0864)
- Kenneth Cardona (ORCID: https://orcid.org/0000-0002-8200-3269)
- Geoffrey T. Gibney (ORCID: https://orcid.org/0000-0002-5401-8498)
- Andrew Elliott (ORCID: https://orcid.org/0000-0001-8494-8031)
- Don S. Dizon (ORCID: https://orcid.org/0000-0001-6541-9580)
- Gina Z. D’Amato (ORCID: https://orcid.org/0000-0001-6981-7527)
- Roman Groisberg (ORCID: https://orcid.org/0000-0001-8970-7675)
- Vaia Florou (ORCID: https://orcid.org/0000-0001-5558-753X)
- Bradley DeNardo (ORCID: https://orcid.org/0000-0002-3721-3523)
- Richard F. Riedel (ORCID: https://orcid.org/0000-0001-5412-8710)
- Michael J. Demeure (ORCID: https://orcid.org/0000-0001-8585-124X)
- Andreas Seeber (ORCID: https://orcid.org/0000-0001-8529-7824)
- Margaret von Mehren (ORCID: https://orcid.org/0000-0001-6158-890X)
- Moh’d Khushman (ORCID: https://orcid.org/0000-0002-3095-5073)
- Galina Lagos
Institutions
- Rutgers, The State University of New Jersey (US)
- Fox Chase Cancer Center (US)
- University of Minnesota (US)
- Hoag Memorial Hospital Presbyterian (US)
- University of Arizona (US)
- Innsbruck Medical University (AT)
- University of Miami (US)
- Emory University (US)
- Georgetown University (US)
- Universität Innsbruck (AT)
- Washington University in St. Louis (US)
- Cornell University (US)
- Brown University (US)
- Huntsman Cancer Institute (US)
- MedStar Georgetown University Hospital (US)
- Piedmont Cancer Institute (US)
- University of Miami Health System (US)
- Banner - University Medical Center Tucson (US)
- Duke Medical Center (US)
- Caris Life Sciences (United States) (US)
- Duke University Health System (US)
- Sylvester Comprehensive Cancer Center (US)
- Weill Cornell Medicine (US)
- Rutgers Cancer Institute (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2503
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52