Changes in Adrenal Function and Insufficiency Symptoms After Cessation of Prednisolone
This cross-sectional study of 267 patients with polymyalgia rheumatica or giant cell arteritis found a GIAI prevalence of 1.9% after cessation of prednisolone. This is much lower than previously reported and speaks against routine screening, which should be restricted to patients with overt symptoms. The high prevalence of symptoms of adrenal insufficiency in association with lower basal cortisol levels substantiate the clinical challenges of steroid withdrawal and merit future research.
Authors
- Marie Lund (ORCID: https://orcid.org/0000-0001-7417-8889)
- Hajir Al-Jorani
- Ellen‐Margrethe Hauge (ORCID: https://orcid.org/0000-0003-2562-9174)
- Ulla Feldt-Rasmussen
- Richard Christian Jensen (ORCID: https://orcid.org/0000-0003-0141-1680)
- Simon Bøggild Hansen (ORCID: https://orcid.org/0000-0002-3699-6159)
- Randi Tei (ORCID: https://orcid.org/0000-0002-0658-011X)
- Louise Lehmann Christensen (ORCID: https://orcid.org/0000-0001-6489-7054)
- Anja Fenger Dreyer (ORCID: https://orcid.org/0000-0001-8079-213X)
- Anne Voss (ORCID: https://orcid.org/0000-0001-6582-2636)
- Kresten Krarup Keller (ORCID: https://orcid.org/0000-0003-2474-3389)
- Dorte Glintborg (ORCID: https://orcid.org/0000-0002-8338-8025)
- Marianne Andersen (ORCID: https://orcid.org/0000-0002-4603-9504)
- Paul M. Stewart (ORCID: https://orcid.org/0000-0002-1749-9640)
- Lise Sofie Bislev (ORCID: https://orcid.org/0000-0002-9720-9518)
- Kristina Laugesen (ORCID: https://orcid.org/0000-0001-7971-8223)
- Henning Locht (ORCID: https://orcid.org/0000-0002-5642-1117)
- Nanna Thurmann Jørgensen (ORCID: https://orcid.org/0000-0002-6945-2035)
- Merete Lund Hetland (ORCID: https://orcid.org/0000-0003-4229-6818)
- Marianne Klose (ORCID: https://orcid.org/0000-0001-6075-0821)
- Victor Brun Boesen (ORCID: https://orcid.org/0000-0003-2792-6738)
- Stina Willemoes Borresen (ORCID: https://orcid.org/0000-0002-3939-3388)
- Jens Otto Lunde Jørgensen (ORCID: https://orcid.org/0000-0001-7408-1526)
- Jelena Stankovic (ORCID: https://orcid.org/0000-0002-4477-8370)
Institutions
- University of Copenhagen (DK)
- University of Leeds (GB)
- University of Southern Denmark (DK)
- Aarhus University (DK)
- Odense University Hospital (DK)
- Glostrup Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Regional Hospital Randers (DK)
- Svendborg Sygehus (DK)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.1029
- Citations
- 7
- Primary Topic
- Adrenal Hormones and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 9.06
Funders
- Eli Lilly and Company
- Pfizer
- Sanofi
- Celgene
- Gigtforeningen
- Novo Nordisk
- NordForsk
- Novo Nordisk Fonden
- Swedish Orphan Biovitrum