Icariin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by activating PI3K-AKT-UTX/EZH2 signaling in steroid-induced femoral head osteonecrosis
Icariin promotes osteogenic differentiation of DEX-treated BMSCs by activating PI3K/AKT signaling to upregulate UTX and inhibit EZH2, finally inducing H3K27me3 depletion.
Authors
- Yuanhang Liu (ORCID: https://orcid.org/0000-0002-0147-8394)
- Wei Ji (ORCID: https://orcid.org/0000-0002-1473-5222)
- Yan Liu (ORCID: https://orcid.org/0000-0002-4054-2803)
- Qiang Li (ORCID: https://orcid.org/0000-0002-1779-0737)
- Guoqing Gong
- Jie Zhang (ORCID: https://orcid.org/0009-0004-5173-9996)
Institutions
- Tongren Hospital (CN)
- Wuhan Third Hospital (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s13018-025-05697-0
- Citations
- 8
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 13.77