Three-Dimensional β-Amyloid Burden Correlation Between the Eye and Brain in Alzheimer's Disease Mice Using Light-Sheet Fluorescence Microscopy
Our observation of a strong correlation between the three-dimensional Aβ burden in the whole eyeball and brain advances our understanding of the systemic nature of Aβ pathology and suggests ocular Aβ as a potential independent predictor of brain Aβ burden.
Authors
- Seon‐Ok Kim (ORCID: https://orcid.org/0000-0001-9010-5460)
- Hye Joo Son (ORCID: https://orcid.org/0000-0003-1290-0949)
- Alice Hahn
- Soo-Jong Kim
- Suk Hyun Lee (ORCID: https://orcid.org/0000-0003-4580-3918)
- Chanwoo Kim (ORCID: https://orcid.org/0000-0001-9914-313X)
- Seog-Young Kim
- Jin Hwa Jung (ORCID: https://orcid.org/0000-0002-8831-1617)
Institutions
- Ulsan College (KR)
- Johns Hopkins University (US)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Hallym University Kangnam Sacred Heart Hospital (KR)
- Mallinckrodt (United States) (US)
- Kyung Hee University Hospital at Gangdong (KR)
- Dankook University (KR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1167/iovs.66.3.34
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Dankook University
- Asan Institute for Life Sciences, Asan Medical Center