Bevacizumab, Atezolizumab, and Acetylsalicylic Acid in Recurrent, Platinum-Resistant Ovarian Cancer: The EORTC 1508-GCG Phase II Study
The addition of ASA to bev plus atezo was well-tolerated but did not improve efficacy in PROC. Relative to bev alone, the bev plus atezo combination numerically improved PFS. Exploratory translational analyses suggest clinical benefit in a subgroup of patients characterized by high TIL infiltration and PD-L1-positive tumors at baseline.
Authors
- Lana E. Kandalaft (ORCID: https://orcid.org/0000-0002-1575-6674)
- Margarita Romeo (ORCID: https://orcid.org/0000-0003-1725-8115)
- George Coukos (ORCID: https://orcid.org/0000-0001-8813-7367)
- Judith R. Kroep (ORCID: https://orcid.org/0000-0003-2671-1903)
- Eleonora Ghisoni
- Matteo Morotti (ORCID: https://orcid.org/0000-0002-1790-1185)
- Corneel Coens (ORCID: https://orcid.org/0000-0001-7601-5450)
- Anita Wolfer (ORCID: https://orcid.org/0000-0002-7109-2286)
- Apostolos Sarivalasis (ORCID: https://orcid.org/0000-0002-3153-297X)
- Petronella B. Ottevanger (ORCID: https://orcid.org/0000-0001-8209-487X)
- Fernanda Herrera (ORCID: https://orcid.org/0000-0001-7984-0472)
- Petr Szturz (ORCID: https://orcid.org/0000-0001-9705-4168)
- Denarda Dangaj Laniti (ORCID: https://orcid.org/0000-0002-5659-6427)
- Susana Banerjee (ORCID: https://orcid.org/0000-0002-8840-7934)
- Julien Dagher (ORCID: https://orcid.org/0000-0003-3864-5149)
- Romuald Le Scodan (ORCID: https://orcid.org/0000-0001-8232-6351)
- Ana Montes (ORCID: https://orcid.org/0000-0001-7657-3356)
Institutions
- University of Geneva (CH)
- Royal Marsden NHS Foundation Trust (GB)
- Radboud University Nijmegen (NL)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Leiden University Medical Center (NL)
- Centre Hospitalier Universitaire Vaudois (CH)
- Radboud University Medical Center (NL)
- Hôpital Beau-Séjour (CH)
- Institut Català d'Oncologia (ES)
- Ludwig Cancer Research (CH)
- Centre Hospitalier privé Saint Grégoire (FR)
- European Organisation for Research and Treatment of Cancer (BE)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
- University of Lausanne (CH)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3368
- Citations
- 8
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 13.58
Funders
- Ludwig Institute for Cancer Research
- Royal Marsden NHS Foundation Trust
- National Institute for Health and Care Research