Tofacitinib for ulcerative colitis in Brazil: a multicenter observational study on effectiveness and safety
In this large, long-term real-world study involving patients with predominantly biologically refractory UC, tofacitinib effectively induced clinical remission and endoscopic improvement and prevented colectomy for more than 30 months, with a favorable safety profile. Notably, baseline hypoalbuminemia was associated with higher colectomy rates.
Authors
- Omar Féres (ORCID: https://orcid.org/0000-0003-3593-0526)
- Renata de Sá Brito Fróes (ORCID: https://orcid.org/0000-0003-3256-4698)
- Fábio Vieira Teixeira (ORCID: https://orcid.org/0000-0002-8915-7279)
- Andréa Vieira (ORCID: https://orcid.org/0000-0003-1858-3446)
- Matheus Freitas Cardoso de Azevedo (ORCID: https://orcid.org/0000-0001-5487-9418)
- Marcos Paulo Moreira Sales (ORCID: https://orcid.org/0000-0002-1449-8386)
- Lígia Yukie Sassaki (ORCID: https://orcid.org/0000-0002-7319-8906)
- Antônio José Tibúrcio Alves (ORCID: https://orcid.org/0000-0002-6795-8526)
- Luísa Leite Barros (ORCID: https://orcid.org/0000-0002-7782-2825)
- Júlio Maria Fonseca Chebli (ORCID: https://orcid.org/0000-0003-1527-0663)
- Munique Kurtz de Mello (ORCID: https://orcid.org/0009-0000-7728-6068)
- Cyrla Zaltman (ORCID: https://orcid.org/0000-0002-5236-6501)
- Marta Brenner Machado (ORCID: https://orcid.org/0000-0003-2266-2542)
- Daniéla Oliveira Magro (ORCID: https://orcid.org/0000-0002-8180-6254)
- Maria Luiza Queiroz de Miranda (ORCID: https://orcid.org/0000-0002-1556-4138)
- Alexandre de Sousa Carlos (ORCID: https://orcid.org/0000-0001-6485-7968)
- Márcio Lubini (ORCID: https://orcid.org/0000-0003-2779-7841)
- Cristina Flores (ORCID: https://orcid.org/0000-0003-1623-4525)
- Adérson Omar Mourão Cintra Damião (ORCID: https://orcid.org/0000-0001-7584-7351)
- Ornella Sari Cassol (ORCID: https://orcid.org/0000-0003-0867-6593)
- Cláudio Saddy Rodrigues Coy (ORCID: https://orcid.org/0000-0002-0916-4138)
- Rogério Serafim Parra (ORCID: https://orcid.org/0000-0002-5566-9284)
- Gilmara Pandolfo Zabot (ORCID: https://orcid.org/0000-0002-1253-4945)
- Sandro da Costa Ferreira (ORCID: https://orcid.org/0000-0001-7698-6599)
- Liliana Andrade Chebli (ORCID: https://orcid.org/0000-0002-7875-1475)
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Universidade Federal do Rio de Janeiro (BR)
- Universidade de Ribeirão Preto (BR)
- Universidade Feevale (BR)
- Faculdade de Medicina de Marília (BR)
- Universidade de Passo Fundo (BR)
- Universidade de São Paulo (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Hospital Moinhos de Vento (BR)
- Hospital Ortopédico de Passo Fundo (BR)
- Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
- Universidade do Vale do Itajaí (BR)
- Clinics Hospital of Ribeirão Preto (BR)
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Pontifícia Universidade Católica de Campinas (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-03-18
- DOI
- https://doi.org/10.1186/s12876-025-03656-x
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82